![]() Shinohara et al ( 1) demonstrated the potential of a medium-chain fatty acid-containing dietary oil, which was found to be effective as an antidepressant in the forced swim test. Nutrition and antioxidant supplements have been considered to be beneficial for the recovery from exercise-induced oxidative stress ( 7). Previous studies reported the benefits of VCO consumption, including antiulcerogenic, antinociceptive, anti-inflammatory ( 4), antihypercholesterolemic ( 5), antimicrobial and hepatoprotective ( 6) effects. VCO has been widely consumed as a health food and has also been utilised for cosmeceutical purposes ( 3). Virgin coconut oil (VCO), which may be produced from fresh coconut meat, coconut milk or coconut milk residue, is rich in medium-chain triglycerides (TGs) and lauric acid ( 3). Thus, stress management through dietary modifications ( 1) and natural herbs ( 2) may be a valuable alternative to antidepressant drugs. However, these drugs may be associated with severe toxicity and side effects ( 2). Various drugs are currently used to manage stress and depression, including diazepam, caffeine and certain anabolic steroids. This condition has increased the number of patients who suffer from depression, affecting their quality of life and, subsequently, the socio-economic balance ( 1). However, extreme stress may compromise mental and somatic health and lead to depression, immunosuppression, hypertension and endocrine disorders ( 2). Stress is a feedback survival response that strengthens the physical and mental status of an individual. Living in a modern society is often associated with more stressful social conditions ( 1). These results suggest the potential value of VCO as an antistress functional oil. Consequently, the serum cholesterol, triglyceride, glucose and corticosterone levels were also lower in VCO-treated mice. Furthermore, mice treated with VCO were found to exhibit higher levels of brain antioxidants, lower levels of brain 5-hydroxytryptamine and reduced weight of the adrenal glands. VCO was able to reduce immobility time and restore oxidative stress in mice post-swim test. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. Medium-chain fatty acids were found to be a potential antidepressant functional food however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. ![]()
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